Contrary to what you may think, acting isn’t always just playing make-believe for a few hours a day while you spend the rest of your time sitting in an air conditioned trailer, sipping margaritas. I mean, sometimes it’s like that. Probably. But, sometimes, acting in a movie can be a tough job. Especially if the script and subject matter is really intense.

Every now and then, even Hollywood’s heartiest, toughest actors take on roles and projects that test them to their limits. And those actors don’t always leave the movie the same way they went in. Sometimes, they’re never the same. To that, we present 25 stories of actors who got seriously f%^&ed up by the movies they were in.